Lisa Vanderpump's Nephew Sam, 28, Reveals 'End-Stage Liver Disease'

Lisa Vanderpump’s nephew, Sam, 28, revealed he has been diagnosed with “end-stage liver disease” and could die in the next four to five years without a vital organ transplant.

Sam, who is cast a member on the U.K. reality show Made In Chelsea, made the revelation during the Monday, October 27, episode in a conversation with costar Ollie Locke.

Sam was previously hospitalized in December 2024 after suffering from kidney and liver failure due to a genetic condition. Upon being admitted to the hospital, he was diagnosed with life-threatening sepsis.

“We had a call from the doctors and I’ve got end-stage liver disease,” Sam said during Monday’s episode of Made In Chelsea on E4. “There is no hope of my liver getting better, and he said, ‘I wouldn’t be having this call with you if I thought you could make it through the next four or five years.’ They’re sending me for a liver transplant assessment.”

When Ollie, 38, asked how Sam how he was feeling, he responded, “The way I look at it, I’m healthy now. Hopefully I remain healthy all the way up until one day [when] they’ll give me a call, and I’ll go in for a surgery. And then I wake up and I’ll be healthier.”

The Vanderpump Rules star’s nephew joined the cast of Made In Chelsea in season 27, which aired last year. The show is currently airing its 30th season and Lisa, 65, made a cameo appearance during a recent episode in which Sam and fiancée Alice Yaxley broke the news to the Bravo star that they are expecting a baby.

Sam and Alice, 24, announced their engagement in March after just six months of dating.

“Alice and I have only been dating for about six months, but we’ve gone through such a lot in such a short period of time. From day dot, Alice has been with me pretty much 24/7,” Sam told OK! magazine at the time. “And over Christmas we went through a bit of an episode together where I got really, really ill. I got an infection due to a genetic disease I’ve got, which led to sepsis and it ended up quite bad. I was in hospital and it was a close call, I could have died.”

“That experience brought us very, very close. I think I walked out of that, looking at Alice and thinking, ‘This is the girl I want to marry.’ So, my thinking was, ‘If I’m saying that now, why on earth am I waiting?’” he added.

In September, the couple announced that they are expecting their first child in a joint Instagram post. “Life is full of surprises, but this is the best one yet. I can’t put into words how happy and excited we are! 🤍,” they wrote alongside a photo of an ultrasound scan and another of Sam kissing Alice’s growing baby bump.