Associate Researcher

Research AssociateFixed Term ContractSouth DublinRole Summary Our Dublin based, Biopharmaceutical Research client is currently searching for a dynamic, hard-working Research Associate to join their team. This position offers a unique opportunity to support Biologics (mAB and recombinant proteins) and Gene Therapy research and development. These dynamic and exciting areas of research have rapidly expanded in recent years, offering novel and real-world treatment options for patients suffering from recalcitrant and life-limiting conditions. Key ResponsibilitiesAttending scheduled training and developing expertise in relevant instrumentation and techniques. Developing and validating methods and Standard Operating Procedures.

Performing experiments with high precision, reproducibility, quality control and validation. Generating and completing records, with precision and accuracy in a timely manner. Troubleshooting experimental issues and bottlenecks to facilitate continued process and operational improvement. To maintain instruments as per appropriate cleaning and maintenance schedules. To design and optimise vectors for biologics and ATMP applications. To develop and validate methods for improved Biologics and Gene Therapy generation, performance, efficacy and applicability across a broader spectrum of applications. To engage in experimental design, development of project structures and plans. To contribute to establishment of efficiencies and operational excellence in laboratory operations.

To support and develop project opportunities with academic and industry groups for advancement of biologics research and ATMP research. To generate and present publication-ready protocols, data and reports to stakeholders collaborators and clients. Essential CriteriaAn MSc and or PhD in biotechnology cell biology, molecular biology or another relevant field. Excellent cell culture skills, including CHO and HEK cell culture. A strong record in Biologics and Gene Therapy development and characterisation. Research experience or industrial experience in biotechnology or biopharmaceuticals. Experience in Biologics development using expression platform(s). Experience of mammalian cell line optimisation, clone isolation, characterisation, and banking. .

Demonstrated capabilities developing mammalian expression technologies for the generation of monoclonal antibodies, recombinant proteins and / or multi-specific proteins. Experience in cloning and vector designDemonstrated capabilities in the genetic manipulation of CHO and HEK cells using gene editing tools. Experience in antibody characterisation techniques for assessment of kinetics, affinity and competitive binding using SPR or other techniques. Hands-on experience in developing and validating Gene Therapy products is advantageous. Experience in RT-PCR, dPCR, Sanger or other types of sequence characterisation.