POST-DOCS IN NEUROSCIENCE (TWO VACANCIES)

Wymagania ObowiązkowePh. D. degree (or equivalent). Scientific productivity proven in publication record. Experience in laboratory work in the field of biology, especially in the field of neuroscience. Leadership and excellent organizational skills. Ability to work in a team. Very good English (both written and spoken). Experience in neuroscience and experiments on mice will be an additional benefit. Knowledge of any of the following techniques will be considered as added value:

immunostaining of cells and tissues, confocal microscopy, Western blot, co-immunoprecipitation, protein purification, molecular cloning, PCR and qRT-PCR, viral-based gene delivery, cell culture, performing experiments on mice, breeding of transgenic and knockout animals. Specific RequirementsThe candidate must meet the requirements of NCN project Regulations, for more information regarding the post-doc role requirements in NCN OPUS 28 check here: https: //www. ncn. gov. pl/sites/default/files/pliki/uchwaly-rady/2024/uchwala84_2024-zal1. pdfOPIS STANOWISKA-NAZWA INSTYTUTU Łukasiewicz – PORT Polski Ośrodek Rozwoju Technologii Codzienne ZadaniaThe Synaptogenesis Research Group is a laboratory conducting multidisciplinary research on the brain, skeletal muscles, and neuromuscular junctions.

Our laboratory is multicultural, with about half of the lab members coming from abroad. We are committed to conducting innovative research at the best international level. Our recent publication Rojek K. et al. , „Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice” published in Plos Biology 2019 May 1;17(5): e3000253 has been awarded the prestigious Konorski Award for the best publication in neuroscience in Poland published in a given year. Our recent publications include: Gessler R. , et al. , Nucleic Acids Res. 2024Kwan HR. , et al. , Sci Adv. 2023Rojek K. et al. , PLoS Biol. 2019Kepser LJ. , et al.

, Proc Natl Acad Sci U S A. 2019We are currently recruiting two postdoctoral researchers for a project funded by the National Science Center (NCN) grant 2024/55/B/NZ3/02433. In this project, we will investigate the role of AMOTL1 in the brain in relation to psychiatric disorders. It is an innovative project, as the functions of AMOTL1 in the central nervous system have not been previously reported. Our laboratory, however, obtained strong preliminary data demonstrating that AMOTL1 regulates a spectrum of important processes in neurons and the brain.

Conditional knockout mice lacking AMOTL1 expression specifically in neurons exhibit a spectrum of behavioral abnormalities characteristic of mouse models of psychiatric disorders. The primary scope of the current project is to dissect the functions of AMOTL1 in specific brain circuits that regulate emotional states and behavior. Our laboratory employs a range of cutting-edge methods, including but not limited to tissue-specific genetic modifications in mice, regulation of gene expression using recombinant AAV viruses, proteomics, RNA sequencing, complex biochemistry, neurotransmitter analysis, confocal microscopy, and cell culture.

By joining the project, you will gain knowledge of various techniques from different fields of biology, and the results obtained will likely be published in reputable international journals. Major ResponsibilitiesPlanning, designing, and conducting scientific experiments. Writing manuscripts, presenting results at international scientific meetings. Active participation in the laboratory operations. Supervising Ph. D. students and technicians. BenefityFull-time contract of employment on the post-doc position (Senior Specialist – Research Engineer);Cutting-edge research with a good publishing record of the group.

Training in the use of modern techniques, including work with conditional knockout mice for tissue-specific deletion, complex biochemistry, protein complex purification, in vivo imaging of synapses, and manipulations of neurons in the brain using AAVs. Co-financing for private medical care. Co-financing for a sports card. Possibility to join group life insurance. Co-financing under the Social Benefits Fund (for holidays and Christmas).