Director, Large-Scale Manufacturing

A leading biopharmaceutical organisation is seeking a Director of Large-Scale Manufacturing to drive operational strategy and excellence across its drug substance production function. This is a rare opportunity to take ownership of high-impact operations in a technically complex, fast-paced environment focused on improving lives through innovative therapies.With a strong pipeline and a culture that values integrity, collaboration, and performance, the company plays a vital role in delivering clinical and commercial manufacturing solutions. Their mission is grounded in science and executed through best-in-class manufacturing processes. Now, they're looking for a senior leader to shape and scale this vital part of their business. Your role as Director of Large-Scale ManufacturingSet and deliver long-term manufacturing strategies that align with organisational goalsLead multi-disciplinary teams responsible for drug substance manufacturing operationsOversee production processes including material prep, cell culture, and bulk manufacturingOwn department KPIs and operational targets, optimising for efficiency, cost, and qualityEnsure consistent compliance with cGMP and all relevant regulatory standardsAct as the manufacturing lead during regulatory inspections and internal auditsDrive a culture of safety, quality, and continuous improvement across all functionsPartner cross-functionally with Quality, Supply Chain, and Engineering teams to resolve issues and implement process improvementsGuide development of site-wide production plans to meet commercial and clinical demandLead CAPEX and OPEX planning, including budget management and resource allocationStay ahead of industry trends to recommend and implement innovative manufacturing solutions Experience and qualifications for the Director of Large-Scale Manufacturing role10+ years of progressive leadership experience in biopharmaceutical or life sciences manufacturingStrong technical knowledge across upstream, downstream, and support operationsDemonstrated success managing large-scale production teams and complex workflowsDeep understanding of cGMP standards, regulatory compliance, and quality systemsProven experience in strategic planning, budget management, and performance monitoringStrong people leadership skills with a focus on mentorship, accountability, and collaborationComfortable leading through change and influencing at senior levelsExcellent problem-solving, decision-making, and communication skillsPreferred:Advanced degree in biochemical engineering, life sciences, or related field15+ years of experience in biologics manufacturing leadership rolesFamiliarity with Lean Manufacturing or Six Sigma methodologiesExperience with digital transformation or smart manufacturing tools Perks and benefitsOpportunity to make a measurable impact in a growing and mission-driven organisationLead a high-performing team in a key strategic roleCompetitive base salary with performance-related bonusesGenerous benefits package including health, retirement, and annual leaveSupportive environment with a focus on career development and learningExposure to cutting-edge science and next-generation manufacturing platforms If you're an experienced manufacturing leader ready to take the next step in your career, apply now for immediate consideration. Alternatively, reach out to discuss similar opportunities in the biopharmaceutical manufacturing space.