Head of In Vivo Antibody Discovery (Director/Senior Director)

Mosaic Biosciences is a biotherapeutics drug discovery company that partners withbiopharmaceutical companies to discover novel protein and antibody therapeutics. Ourexperienced and dedicated research teams collaborate with our partners to design, manage, andexecute research programs to rapidly advance clinical candidates, starting at any point from earlydiscovery into preclinical development. We are seeking a driven and motivated Inside SalesRepresentative to drive our business growth through commercial sales support.Position OverviewWe are hiring a full-time Head of In Vivo Antibody Discovery to lead our In Vivo AntibodyDiscovery team at Mosaic. This role will be responsible for designing, building, and optimizinghybridoma and single B cell screening workflows to support Mosaic partners’ therapeuticantibody discovery programs. This is a hands-on scientific leadership role that combines deeptechnical expertise with the opportunity to build and scale a new capability area within thecompany. The ideal candidate will bring significant experience in immunization strategies anddownstream hybridoma and single B cell screening techniques and will be passionate aboutdelivering high-quality candidate molecules to support our partners’ discovery pipelines. Thiscandidate will lead a small but growing team and work cross-functionally with colleagues inprotein engineering, expression, characterization, and functional assays to drive seamless,integrated antibody discovery campaigns.Key ResponsibilitiesDesign and oversee in vivo antibody discovery campaigns, including immunization strategies, screening approaches, and hit selectionBuild and optimize robust hybridoma and single B cell workflows suitable for diverse therapeutic targets, multiple species, and various immunogen formatsLead a team of scientists and associates, providing mentorship and scientific guidance while ensuring technical excellenceWork closely with the project leadership team to align in vivo strategy with partner goals and broader campaign objectivesCollaborate with upstream (antigen design) and downstream (screening) groups to ensure seamless handoffs and rapid data generationServe as a subject matter expert in external meetings with partners as neededDrive innovation by evaluating and implementing new technologies, including AI/ML approaches, to improve workflow efficiency and candidate qualityQualifications:Ph.D. (or equivalent) in Immunology, Cell Biology, Molecular Biology, or related field with 8+ years of experience in in vivo antibody discovery (or MS with 12+ years) Deep expertise in murine immunization, hybridoma generation, and single B cell screening technologiesExperience building and leading high-performing scientific teamsTrack record of delivering therapeutic antibody leads through in vivo discovery workflowsExcellent organizational, communication, and leadership skillsExperience in a CRO setting is strongly preferredLocation: This is a full-time, in-person position based in Boulder, COCompensation Range: $155,000 - $200,000 (Title and compensation will be determined based on experience and level)Mosaic offers competitive, flexible benefits, including health and dental insurance, disability and life insurance, 401k with company match, and bonus opportunities based on company success.Powered by JazzHR