PhD Student in Physiology

PhD student position: Molecular and functional identification of regulators of phosphate balance We are a leading laboratory in renal physiology with a focus on phosphate and acid base homeostasis. We are seeking a highly qualified and motivated PhD student with a degree in Biology, Biomedicine, Pharmacy, Molecular Biology, Physiology or related fields to join our research team at the Institute of Physiology, University of Zurich.Phosphate is an essential mineral that must be absorbed from diet. Phosphate balance is determined by phosphate sensing, intestinal absorption and renal reabsorption. Whereas renal reabsorption and apical intestinal absorption is well understood, the other processes are poorly understood. Preliminary data on paracellular transport in our laboratory suggest proteins that might be responsible for the bulk of intestinal phosphate absorption. Moreover, data from large genetics screens have revealed candidates to play a role in modulating phosphate balance. The position:The aims of the PhD project are 1) to identify candidate molecules involved in phosphate fluxes and balance using a combination of bioinformatic tools, data from large genetic screens, and CRISPR/Cas, 2) validate candidates in cellular models, 3) deep phenotyping of transgenic animal model to validate candidates in vivo, and 4) test potential new drug candidates to modulate phosphate balance.Conduct cutting-edge research in physiology, with a focus on the (patho)biology of phosphate, its epithelial transport and endocrine regulation, using mouse and cell culure models and (data-rich) human studies.Publish research findings in high-quality scientific journals.Effectively communicate scientific concepts through oral presentations and written reports.Contribute to teaching of graduate and undergraduate students.Qualifications:master degree in Biology, Molecular Biology, Pharmacy, Biomedicine, Human Biology, Physiology or a related fieldStrong knowledge in renal and/or intestinal physiology, endocrine functions, cell biology, microbiology, cell signaling, and protein trafficking.Experience in working with animals and/or cell culture is a plus.Experience in analyzing large datasets is a plus.Excellent writing and communication skills in English.Ability to critically assess research results.Ability to work both independently and in a team.The successful candidate must be accepted into one of the PhD programs of the Life Science Graduate School Zurich via track I or II (see https://www.lifescience-graduateschool.uzh.ch)We Offer:A stimulating and collaborative working environment. We are an international team with diverse backgrounds.The annual salary is based on the recommended salaries by the Swiss National Science FoundationStart of employment:as soon as possible. Review of applications will start December 15, 2025 until the position is filled.How to Apply:Interested candidates are invited to submit their applications as a single pdf, including a cover letter, curriculum vitae, transcripts of records. and contact information for two professional references, to carsten.wagner@physiol.uzh.chThe University of Zurich is an equal opportunity employer. We encourage applications from candidates of all backgrounds and experiences.