Postdoc Neurosurgery

Job DescriptionBrain tumors, particularly glioblastoma, are among the most aggressive cancers, with no curative treatments currently available. Recent clinical trials investigating immunotherapy with oncolytic viruses (OVs) have shown promising results, although only a subset of patients achieve durable responses.As a postdoc, you will contribute to identifying tumor-, microenvironment-, and host-related factors that influence response to OV therapy. To achieve this, you will develop and compare ex vivo model systems derived directly from patient tumor tissue and blood. These models will be evaluated in parallel with an upcoming clinical trial at our department testing an oncolytic adenovirus, with the aim of assessing their predictive value. In addition, you will be involved in trial-associated studies that map immune responses to OV treatment in patients.